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Toxicological information

Dermal absorption

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Administrative data

Endpoint:
dermal absorption
Type of information:
other: Expert statement
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
other: expert statement
Title:
Unnamed
Year:
2012
Report date:
2010

Materials and methods

Test guideline
Qualifier:
no guideline required
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Lithium carbonate
EC Number:
209-062-5
EC Name:
Lithium carbonate
Cas Number:
554-13-2
Molecular formula:
CH2O3.2Li
IUPAC Name:
dilithium carbonate

Results and discussion

Any other information on results incl. tables

Due to the chemical properties of an inorganic salt , the dermal absorption of lithium carbonate is expected to be very poor. Based on (1) the hydrophilic character of lithium carbonate and (2) the barrier function of the stratum corneum against salts, dermal absorption can practically be excluded. Dermal toxicity values revealed LD50 values > 2000 mg/kg bw, which further supports this conclusion. 10 % absorption was used for DNEL deduction. Thus, this presents a worst case.

Applicant's summary and conclusion

Conclusions:
The absorption of lithium carbonate through skin is considered to be very poor.
Executive summary:

Expert statement: Due to the chemical properties of an inorganic salt, the dermal absorption of lithium carbonate is expected to be very poor. Based on (1) the hydrophilic character of lithium carbonate and (2) the barrier function of the stratum corneum against salts, .