Registration Dossier
Registration Dossier
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EC number: 203-618-0 | CAS number: 108-80-5
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- no
Test material
- Reference substance name:
- Cyanuric acid
- EC Number:
- 203-618-0
- EC Name:
- Cyanuric acid
- Cas Number:
- 108-80-5
- Molecular formula:
- C3H3N3O3
- IUPAC Name:
- 1,3,5-triazine-2,4,6-triol
- Details on test material:
- - Name of test material (as cited in study report): Crude cyanuric acid
- Physical state: Solid balls
- Lot/batch No.: 3-30-81
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Isaac’s Farm, Litchfield, Illinois, USA
- Age at study initiation: Young adult
- Weight at study initiation: 2.34 - 3.13 kg
- Diet (e.g. ad libitum): Provided ad libitum
- Water (e.g. ad libitum): Provided ad libitum
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- abraded
- Vehicle:
- physiological saline
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount applied: 500 mg
- Duration of treatment / exposure:
- 24 hour(s)
- Observation period:
- 72 hours
- Number of animals:
- 6
- Details on study design:
- TEST SITE
- Area of exposure: Dorsal surface
- Type of wrap if used: Latex rubber
REMOVAL OF TEST SUBSTANCE
- Time after start of exposure: 72 hours
SCORING SYSTEM: Draize
Results and discussion
In vivo
Results
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- other: 72 h
- Score:
- 0
- Max. score:
- 8
- Irritant / corrosive response data:
- Slight irritation to one abraded site of one male animal was observed on the first day after exposure, while skins of the remaining five rabbits remained normal throughout the study.
Any other information on results incl. tables
Table 1: Primary skin irritation to rabbits -Individual irritation scores
Animal number |
Period (days) |
Erythema |
Edema |
||||||
RFI |
LBI |
LFA |
RBA |
RFI |
LBI |
LFA |
RBA |
||
01M01 |
1 |
0 |
0 |
0 |
1 |
0 |
0 |
0 |
0 |
01M02 |
1 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
01M03 |
1 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
01F01 |
1 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
01F02 |
1 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
01F03 |
1 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
|
|
|
|
|
|
|
|
|
01M01 |
3 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
01M02 |
3 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
01M03 |
3 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
01F01 |
3 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
01F02 |
3 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
01F03 |
3 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
The primary irritation index for this group of animals is 0.0 on a scale of 0.0 to 8.0. Slight irritation to one abraded site of one male animal was observed on the first day after exposure, while skins of the remaining five animals appeared normal throughout the study. One male rabbit showed slight irritation to one of the abraded sites on one day but the remaining five animals appeared normal throughout the study.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Cyanuric acid is not irritating
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