Registration Dossier
Registration Dossier
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EC number: 260-906-9 | CAS number: 57693-14-8
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
The results of basic toxicity testing give no reason to anticipate unusual characteristics with regard to the toxico-kinetics of the substance.
The data indicates that there is little dermal absorption. On the other hand, it is absorbed from the gastro-intestinal tract in toxicologically significant amounts. Indications of a bio-accumulative potential as well as a metabolism do not exist. Excretion of systemically available substance and/or metabolites via the kidney can be assumed.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
Based on all available data, the substance does not exhibit conspicuous toxicokinetic behaviour in the sense of accumulative and/or delayed effects with regard to the individual parameters absorption, distribution, metabolism and excretion.
Results from studies with dermal exposure indicate that the substance has a small but definite dermal absorptive potential. The substance is absorbed from the gastrointestinal tract in significant amounts and distributed throughout the body.
Indications of an intense metabolism or a bio-accumulative potential do not exist as no delayed toxicity occurred. Additionally no increase in severity of systemic effects was observed in the subacute oral toxicity study, which also points to no bio-accumulation potential as well as to excretion of the substance.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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