Registration Dossier
Registration Dossier
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EC number: 203-005-8 | CAS number: 102-09-0
Endpoint summary
Administrative data
Description of key information
Additional information
Short term toxicity to fish
The toxicity of diphenyl carbonate to fish (Danio rerio) was assessed according to EU Method C.1 (Bayer, 1994). The effective concentrations LC0 and LC100 were determined to be 0.91 and 5.6 mg/L, respectively (geometric mean over time). By graphic interpolation (linear) the resulting 96 h LC50 was determined to 3.9 mg/L.
Short term toxicity to aquatic invertebrates
The toxicity of diphenyl carbonate to aquatic invertebrates (Daphnia magna) was assessed according to EU Method C.2 (Bayer, 1999a). The effective concentration 48 h EC50 was determined to be 6.5 mg/L by graphic interpolation (linear).
Toxicity to aquatic algae
The toxicity of diphenyl carbonate to algae (Desmodesmus subspicatus) was assessed according to EU Method C.3 (Bayer, 1999b). A 72 h NOEC for growth rate of 0.22 mg/L (effective concentration) and an EC50 of 0.9 mg/L (effective concentration) were determined.
Assessment of the aquatic toxicity should however consider the uncertainty in the reported results. There does not appear to be sufficiently robust information available to warrant the use of the reported EC50 value of 0.9 mg/L for classification purposes concerning environmental toxicity hazard, as this is an estimated effective concentration.
In the supporting study (Smithers, 2010), the toxicity of the test material to algae was calculated using ECOSAR v1.00 (EPI Suite v4.0) March 2009. The predicted EC50 for green algae is 3.66 mg/L (96 h).
As a conclusion from the hazard assessment, when both the key and supporting data are taken into consideration, the toxicity of diphenyl carbonate towards algae is considered be with an EC50 value > 1 mg/L.
Toxicity to microorganisms
The toxicity of diphenyl carbonate to activated sludge was assessed using methodology comparable to OECD 209 (Bayer, 2000c). A 3 h EC10 of 60 mg/L and a 3 h EC50 of 4510 mg/L were determined.
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