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EC number: 225-208-0 | CAS number: 4719-04-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 997
- Report date:
- 1997
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- no
- Principles of method if other than guideline:
- A single dermal dose of the undiluted test substance was applied to one group of 10 Wistar rats (5 males and 5 females) at a dose level of 4000 mg/kg bw (3.43 mL/kg). The test material was applied to the clipped epidermis (dorsal and dorsolateral parts of the trunk) of each animal and was covered by a semiocclusive dressing for 24 hours. Post-observation period: 14 days.
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 2,2',2''-(hexahydro-1,3,5-triazine-1,3,5-triyl)triethanol
- EC Number:
- 225-208-0
- EC Name:
- 2,2',2''-(hexahydro-1,3,5-triazine-1,3,5-triyl)triethanol
- Cas Number:
- 4719-04-4
- Molecular formula:
- C9H21N3O3
- IUPAC Name:
- 2,2',2''-(1,3,5-triazinane-1,3,5-triyl)triethanol
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Lot/batch No.of test material: PK 95/222
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: refridgerated
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Dr. K. Thomae GmbH, Biberach
- Age at study initiation: Young adult animals
- Weight at study initiation: 200-300 g
- Fasting period before study: > 15 h
- Housing: Single housing in fully air-conditioned rooms.
- Diet (ad libitum): Kliba-Labordiaet 343 (Klingentakmuehle AG, Kaiseraugst, Switzerland)
- Water (ad libitum): tap water
- Acclimation period: for at least 1 week
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20-24
- Humidity (%): 30-70
- Photoperiod (hrs dark / hrs light): 12 h/12 h
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: about 50 cm²
- Type of wrap: The bandage consisted of four layers absorbent Gauze and fixomull stretch (adhesive fleece).
REMOVAL OF TEST SUBSTANCE
- Washing: with warm water
- Time after start of exposure: 24 h
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 3.43 mL/kg
- Concentration: undiluted
- Duration of exposure:
- 24 h
- Doses:
- 4000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: Individual readings 30 - 60 min. after removal of the semiocclusive dressing (day 1), at least once each workday.
- Necropsy of survivors performed: yes.
- Other examinations performed: clinical signs, body weight, scoring of skin findings. - Statistics:
- Statistical analysis: Binomial test (Snedecor and Cochran, 1989).
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 4 000 mg/kg bw
- Mortality:
- No mortality observed.
- Clinical signs:
- other: Systemic signs of toxicity were not noted.
- Gross pathology:
- No pathologic findings noted. No abnormalities were noted at necropsy of animals sacrified at the end of the study.
- Other findings:
- The following local effects were observed 1 day or 7 days after application: very slight, well-defined or moderate erythema, very slight to slight edema, scaling and superficial scabbing.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
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