Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

HBCDD did not induce sensitisation in a mouse local lymph node assay or in a guinea pig maximisation study. Both studies were conducted according to international guidelines and GLP using a composite of commercial products from three manufacturers (i.e. Albemarle, Chemtura and ICL-IP). Earlier studies performed in Japan using a test substance of unknown composition reported positive results. These studies were not conducted according to GLP nor current guidelines. For the test substance provided by Albemarle, Chemtura and ICL-IP it can be concluded that HBCDD does not have skin sensitising potential. This was also concluded in the EU Risk Assessment Report (EC, 2008).


Migrated from Short description of key information:
The following information is available for this endpoint:
Guinea pig maximisation: Wenk, M. L. (1996). Maximisation test in Guinea Pigs. Report no.: M96AO61.1X64. Report date: 1996-11-08.

Mouse local lymph node assay: Woolhiser, M. R. and Anderson, P. K. (2003). Hexabromocyclododecane: Contact sensitisation potential via the local lymph node assay (including a primary irritancy screen) using CBA/J mice. Report no.: 031013. Report date: 2003-07-14.

Respiratory sensitisation

Endpoint conclusion
Additional information:

No information was available for respiratory sensitisation. As HBCDD is not a skin sensitiser and no cases of respiratory sensitisation have been reported in the literature, the substance is unlikely to have respiratory sensitisation potential.


Migrated from Short description of key information:
No information was available for respiratory sensitisation. As the substance is not skin sensitising and no cases of respiratory sensitisation have been reported in the literature, HBCDD is unlikely to have a respiratory sensitisation potential.

Justification for classification or non-classification

Based upon the results of the key study (Woolhiser and Anderson, 2003), HBCDD does not meet the criteria for classification according to 67/548/EEC and EC Regulation 1272/2008.