Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 247-148-4 | CAS number: 25637-99-4
Water solubility
Administrative data
Link to relevant study record(s)
Description of key information
The following information was available for this endpoint:
Stenzel, J.I. and Markley, B.J. (1997) Hexabromocyclododecane (HBCD): Determination of the water solubility. Wildlife International Ltd., 8598 Commerce Drive, Easton, Maryland 21601. 439C-105. Chemical Manufacturers Association's Brominated Flame Retardant Industry Panel, 1300 Wilson Boulevard, Arlington, Virginia 22209. 13/06/1997.
MacGregor, J.A. and Nixon, W.B. (2004) Determination of water solubility of Hexabromocyclododecane (HBCD) using a generator column method. Wildlife International, Ltd., 8598 Commerce Drive, Easton, Maryland 21601, USA. 439C-138. European Brominated Flame Retardant Industry Panel, Brussels, Belgium. 29/03/2004.
Desjardins, D., MacGregor, J.A. & Krueger, H.O. (2004) Hexabromocyclododecane (HBCD): A 72-hour toxicity test witht the Marine Diatom (Skeletonema costatum). Appendix 1: NON-GLP Preliminary Trials. Wildlife International, Ltd., 8598 Commerce Drive, Easton, Maryland 21601, USA. 439A-125. European Brominated Flame Retardant Industry Panel, Brussels, Belgium. 18/02/2004.
MacGregor and Nixon, 2004, was selected as the key study based upon the reliability score of 1 which was assigned according to the criteria of Klimisch et al. (1997). The reliability score was based upon the study conducted according to a recognised testing guideline and under GLP conditions.
Both Stenzel and Markley (1997) and Desjardins et al. (2004) were allocated the reliability score of 2 according to the criteria of Klimisch et al. (1997).
For Stenzel and Markley (1997) this score was based upon the standard test guidelines used for the test and also the GLP conditions in force throughout the test. The reliability score was reduced from 1 to 2 as minor deviations which may have affected the results of the study were reported in the study report.
Desjardins et al. (2004) was conducted in a very similar way to standard test guidelines for this endpoint, but with no GLP compliance.
Key value for chemical safety assessment
- Water solubility:
- 65.6 µg/L
- at the temperature of:
- 20 °C
Additional information
MacGregor & Nixon, 2004, reported the following result using the generator column method:
Ca. 65.6 µg/l at 20ºC
This result is supported by Desjardins et al, 2004 which reported results of 67.7 -78.9 µg a.i./L using a similar generator column method. Stenzel & Markley, 1997, reported a result of 3.4 µg/l at 25ºC using a generator column method. It was therefore considered appropriate to use the value of 65.6 µg/l at 20ºC as a 'worst case' value.
This result means that the registered substance is highly insoluble (<0.01 mg/l in water).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
