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EC number: 920-360-0
CAS number: -
This data is
being read across from the source study that tested pristane based on
analogue read across.
The fate of pristane (2, 6, 10,
14-tetramethylpentadecane) was studied in rats after a single per os
administration of 3H-labeled pristane. The balance study showed
extensive fecal excretion (66%) mainly as unchanged hydrocarbon, whereas
about 14% of ingested pristane was excreted in urine as pristane
metabolites and tritiated water. After one week, 8.3% of the ingested 3H
still was stored in the carcass and the radioactive distribution in
tissues and organs showed a preferential incorporation into adipose
tissue and liver. Over 75% of the radioactivity stored in the carcass
was associated with pristane metabolites and tritiated water. Tissue
metabolites were characterized by thin layer chromatography, gas
chromatography, and mass spectrometric analyses. Four metabolites were
identified: pristan-1-ol, pristane-2-ol, pristanic acid and 4, 8,
12-trimethyltridecanoic acid. These results demonstrated that pristane
undergoes subterminal hydroxylation or terminal oxidation followed by
the classical beta-oxidation process. Incorporation of metabolites in
phospholipids and more particularly in the phosphatidylserine fraction
has been observed.
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