Registration Dossier
Registration Dossier
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EC number: 231-853-9 | CAS number: 7761-88-8
Endpoint summary
Administrative data
Description of key information
The acute oral, dermal and inhalation toxicity studies have been waived in accordance with the column 2 of the Annex VII of REACh Regulation: the study does not need to be conducted as the substance is classified as corrosive to the skin (Category 1A).
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study does not need to be conducted because the substance is classified as corrosive to the skin
Reference
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study does not need to be conducted because the substance is classified as corrosive to the skin
Reference
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study does not need to be conducted because the substance is classified as corrosive to the skin
Reference
Additional information
Justification for classification or non-classification
Silver nitrate is corrosive to skin and eyes. Thus, any acute toxicity testing (oral, dermal or inhalation) in animals is not justifiable for silver nitrate based on animal welfare considerations. The acute toxicity of other silver compounds is generally low (LD50, oral all >2000 mg/kgbw for Ag, Ag2O, Ag2CO3, Ag2SO4, AgCl), indicating an overall low systemic toxicity and bioavailability of silver, which is assumed to also pertain to silver nitrate, since the nitrate anion itself is not expected to contribute to a relevant extent to overall toxicity. In consequence, no hazard classification for acute toxicity is required.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
