Registration Dossier

Diss Factsheets

Toxicological information

Exposure related observations in humans: other data

Administrative data

Endpoint:
exposure-related observations in humans: other data
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Secondary literature.

Data source

Reference
Reference Type:
publication
Title:
IARC Monographs on the evaluation of the carcinogenic risk of chemicals to humans. The rubber industry.
Author:
IARC, IARC monographs on the evaluation of the carcinogenic|risk of chemicals to humans. The rubber industry, Vol. 28.|International Agency for Research on Cancer, Lyon (1982)
Year:
1982
Bibliographic source:
IARC. Vol. 28, p132.

Materials and methods

Type of study / information:
Occupational exposure
Principles of method if other than guideline:
no data
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
1,3-diphenylguanidine
EC Number:
203-002-1
EC Name:
1,3-diphenylguanidine
Cas Number:
102-06-7
Molecular formula:
C13H13N3
IUPAC Name:
1,3-diphenylguanidine
Details on test material:
no data

Method

Details on study design:
no data
Exposure assessment:
not specified
Details on exposure:
no data

Results and discussion

Results:
At an employee who was working in the area of weigh out- and preparation-procedure in a tyre factory, a work-place concentration of 0.26 mg/mE3 test substance was measured by the US Occupational Safety and Health Administration (1980).
Others organic materials were measured (e.g. 2-morpholinothiobenzothiazole).

Applicant's summary and conclusion