Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 221-625-7 | CAS number: 3164-85-0
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Information was taken from several review documents published by national and international agencies (e.g. EFSA, EGVM) on human health aspects of minerals in human nutrition. This information represents the highest level of reliability and acceptance.
Data source
Referenceopen allclose all
- Reference Type:
- review article or handbook
- Title:
- Opinion of the Scientific Panel on Dietetic Products, Nutrition and Allergies on a request from the Commission related to the tolerable upper intake level of potassium
- Author:
- EFSA
- Year:
- 2 005
- Bibliographic source:
- The EFSA Journal 193: 1 - 19.
- Reference Type:
- review article or handbook
- Title:
- Potassium
- Author:
- EGVM
- Year:
- 2 003
- Bibliographic source:
- In: Safe upper levels for vitamines and minerals, Expert Group on vitamines and Minerals (EGVM) publsihed by Food Standards Agency (FSA), 1-361.
- Reference Type:
- publication
- Title:
- 23. Potassium
- Author:
- EFSA
- Year:
- 1 993
- Bibliographic source:
- In: Report of the Scientific Committee for Food, 31th series, Nutrient and energy intakes for the European Community: 170-174.
Materials and methods
- Objective of study:
- absorption
- distribution
- excretion
- Principles of method if other than guideline:
- Information was taken from several review documents published by national and international agencies (EFSA, EGVM) on human health aspects of minerals in human nutrition. This information represents the highest level of reliability and acceptance.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Potassium salts
- IUPAC Name:
- Potassium salts
- Test material form:
- other: via diet
Constituent 1
Test animals
- Species:
- human
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- other: diet
- Details on exposure:
- dietary intake
- Duration and frequency of treatment / exposure:
- daily
Results and discussion
Main ADME resultsopen allclose all
- Type:
- absorption
- Results:
- about 85 - 90% of the dietary potassium is normally absorbed from the gut
- Type:
- distribution
- Results:
- 98% of potassium in the body is found in the cells (main intracellular cation). 2% of potassium is found extracellularly.
- Type:
- distribution
- Results:
- Potassium can be found in a high concentration in muscle, skeleton, blood, central nervous system, intestine, liver, lung and skin
- Type:
- excretion
- Results:
- The potassium balance is primarily regulated by renal excretion in urine. The major excretory route of potassium is via the kidneys.
- Type:
- excretion
- Results:
- Excretion in sweat and faeces is negligible, the latter changing only slightly as dietary potassium intake varies over a wide range.
- Type:
- excretion
- Results:
- the maximum excretion rate following an oral dose of 8 g potassium chloride (4.2 g potassium) was up to 130 µmol potassium/minute (5 g potassium/minute).
Metabolite characterisation studies
- Metabolites identified:
- no
- Details on metabolites:
- Potassium as inorganic cation is void of metabolism.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): other: bioaccumulation potential is not relevant since K is an essential element in human nutrition
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
