Registration Dossier
Registration Dossier
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EC number: 265-044-7 | CAS number: 64741-44-2 A complex combination of hydrocarbons produced by the distillation of crude oil. It consists of hydrocarbons having carbon numbers predominantly in the range of C11 through C20 and boiling in the range of 205°C to 345°C (401°F to 653°F).
Specific investigations: other studies
Administrative data
Link to relevant study record(s)
Description of key information
A supporting study on photoirritation resulted in severe photoirritation in rabbits when exposed to gas oil intermediate and UV A light.
Additional information
In a primary dermal photoirritation study five female New Zealand White rabbits were exposed to 0.3 mL of gas oil intermediate for one hour and exposed to 6.06 hours of 10J/cm^2 to UV A light. Animals were observed 30 minutes, 24, 48, 72 hours after UV A exposure (ARCO, 1991b).
A positive response was achieved with the 1% 8-MOP (a known photoirritant). The Irritation Index (based on 24 and 72 hours) is 5.4 for 1% 8-MOP exposed to UV A light and 0.0 for 1% 8-MOP not exposed to UV A light. The photoirritation for 1% 8-MOP is 5.4, therefore the 1% 8-MOP is considered to be a moderate photoirritant. The irritation index is 7.0 for the Gas Oil Intermediate exposed to UV A light and 1.0 for gas oil intermediate is 6.0. Based on these values gas oil intermediate is considered to be a severe photoirritant under the conditions of this test.
Additional data on other studies are presented in the dossier (DGMK, 1993; Jungen et al., 1995).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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