Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 206-114-9 | CAS number: 302-01-2
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: application of the test substance is not relevant for the human situation; information insufficient for assessment: no clear information about the test substance.
Data source
Reference
- Reference Type:
- publication
- Title:
- Poisoning of the rat by hydrazine and alkylhydrazines.
- Author:
- O'Brien RD et al.
- Year:
- 1 964
- Bibliographic source:
- Toxicol. Appl. Pharmacol. 6, 371-377
Materials and methods
- Principles of method if other than guideline:
- A total of 47 females were used (no details given).
- GLP compliance:
- no
Test material
- Reference substance name:
- Automatically generated during migration to IUCLID 6, no data available
- IUPAC Name:
- Automatically generated during migration to IUCLID 6, no data available
- Details on test material:
- IUCLID4 Test substance: A01-03:hydrazine-2HCl or hydrazine
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Holtzmann
- Sex:
- female
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- other: HCl
- Doses:
- 11 doses, range of 20-256 mg/kg bw hydrazine or hydrazine hydrochloride
- No. of animals per sex per dose:
- a total of 47 females were used
- Control animals:
- other: migrated dataset
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 64 mg/kg bw
Any other information on results incl. tables
Primary symptom extreme lethargy; lack of muscle tone; tonic convulsions at doses > LD50; drop in body temperature; most deaths occurred 3-6 h after injection; blood glucose elevated during preconvulsion period.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
