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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Dermal absorption

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Administrative data

Endpoint:
dermal absorption in vivo
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: results presented as graphics only

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1984
Report date:
1984

Materials and methods

Principles of method if other than guideline:
hydrazin solutions in various aqueous concentrations were applied to the skin of rabbits over selected time periods and serum hydrazin concentrations were determined
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Hydrazine
EC Number:
206-114-9
EC Name:
Hydrazine
Cas Number:
302-01-2
Molecular formula:
H4N2
IUPAC Name:
hydrazine
Details on test material:
anhydrous hydrazine, hydrazine 70 %,, hydrazine 15 % and 2 % hydrazine solution
Radiolabelling:
not specified

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified

Administration / exposure

Type of coverage:
not specified
Vehicle:
other: no vehicle or water
Duration of exposure:
up to 12 minutes
Doses:
Anhydrous hydrazine, hydrazine 70 %,, hydrazine 15 % and 2 % hydrazine solution.
No. of animals per group:
no data

Results and discussion

Signs and symptoms of toxicity:
not specified
Dermal irritation:
yes
Absorption in different matrices:
for available information see section remarks on results
Total recovery:
for available information see section remarks on results

Any other information on results incl. tables

RM-Freetext: (graphics only)
Result: time-limitation of percutaneous Hz exposure (2, 6, 12 minutes) demonstrated a direct correlation between duration of exposure and peak serum. Hydrazine concentrations for both Hz and Hz70%. A correlation of time to peak serum Hz level with duration of Hz exposure was also evident with anhydrous Hz but not Hz70%. Serun Hz levels peaked at 50 -90 min for anhydrous Hz and at 30 -50 min for Hz70%. Total percutaneous Hz absorption from anhydrous Hz or Hz70% was also directly related to duration of Hz exposure. In addition the rate of Hz absorption was greater for anhydrous Hz than for Hz70% . The peak serum Hz concentration was greater for Hz15% than for Hz2%. These peak serum Hz concentration occurred at 30 min for Hz15% and at 10 min for Hz2%. There was an increase in the percent Hz dose absorbed as the Hz solution concentration increased. tissue evaluation: severe chemical burns were found in rabbits percutaneously exposed to annydrous Hz or Hz70%. These lesions typically contained areas of transepidermal necrosis with varying degrees of dermal necrosis. No significant lesions were noter following percutaneous exposure to Hz15% or Hz2%.

Applicant's summary and conclusion

Executive summary:

Hydrazin is absorbed through the skin of rabbits (Keller 1984).