Registration Dossier
Registration Dossier
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EC number: 305-871-3 | CAS number: 95193-59-2
Endpoint summary
Administrative data
Description of key information
The terrestrial ecotoxicity of the item was tested with three different soil organisms and biological processes: plants (emergence and growth), microorganisms (N-transformation), earthworm (reproduction).
The lowest long-term ecotoxicity values in the OECD-208, OECD-216 and OECD-222 were EC10 = 176.9 mg/kg soil dw,
EC10 = 182 mg/kg soil dw and NOEC >=1000 mg/kg soil dw, respectively.
Therefore, the effect on plant fresh shoot weight, EC10 = 176.9 mg/kg soil dw, will be used as the reference value for the terrestrial toxicity.
Additional information
The substance is considered to be readily biodegradable, but it has potential to adsorb to soil (Log Koc > 4.96). Therefore long-term toxicity studies on soil organisms were performed as indicated in Annex IX, Column 2 and short term tests were waived.
The study organisms represent different ecological functions and trophic levels in the terrestrial ecosystem: 6 plant species (production), earthworms (detritus feeding and improvement of the soil structure) and a soil flora representing the nitrification capacity.
A study on the toxicity to birds was waived.
All studies were performed according to standard OECD test guidelines and under GLP. They were valid studies with reliability 1.
The results are summarised in the table (concentrations in mg/kg soil dw):
Terrestrial Toxicity test |
Result (nominal) mg/kg soil dw <95%> |
Result (nominal) mg/kg soil dw <95%CL> |
Plants, 18 d OECD 208 |
EC10 =176.9 <2.8-315.5> |
EC50 = 707.1 <472.1-2402.7> |
Earthworm, 56 d OECD 222 |
NOEC ≥ 1000 |
EC50 > 1000 |
N-transformation, 28d, OECD 216 |
EC10 =182 |
EC50 = 582 |
It should be noted that the test substance is highly insoluble in water, and had to be spiked into the soil through an artificial method to enhance its inclusion (solution in acetone, adsorption onto sand grains with evaporation of the solvent, and finally the mixing of this coated sand with soil). Therefore, the measured effects should be considered as a very worst case that does not reflect the possible availability in a realistic soil environment.
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