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Developmental toxicity / teratogenicity

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developmental toxicity
Species 1 (rat)
Data waiving:
study technically not feasible
Justification for data waiving:
Justification for type of information:
Tests in aqueous media with ethyl 2-cyanoacrylate with the intent to determine effective concentrations or no effect concentrations can not be performed due to technical reasons based on the chemical properties of the monomer. In presence of moisture ethyl 2-cyanoacrylate polmerises within seconds (inherent property of ethyl 2-cyanoacrylate based instant glues). Thus, very low determined monomer concentrations in water represent a non already state situation from which a defined effective concentration can not be derived. Oral administration would be the most appropriate way. The monomer would polymerized in the oral cavity or when administered by gavage in the stomach. The application in the feed is not possible, as the monomer polymerizes immediately on contact with food. This would allow only the polymer to be tested.

Data source

Materials and methods

Test animals


Results and discussion

Applicant's summary and conclusion