Ethyl 2-cyanoacrylate

Repeated dose toxicity: inhalation

Administrative data

Endpoint:

chronic toxicity: inhalation

Data waiving:

study technically not feasible

Justification for data waiving:

other:

Justification for type of information:

When in breathing atmosphere, mixing of ethyl 2-cyanoacrylate vapors with moisture (water vapors) of will therefore cause in the air fast polymerization of the substance required to be applied in the inhalation studies. Therefore, the successful competition of these in vivo studies will not be possible since the outcome will be influenced by the in-air polymerization that will lead to extremely low concentrations of the free monomers. Thus, test chemical cannot be generated as a gas, vapour, or aerosol in sufficient concentration to elicit animal toxicity in the optimal conditions of an inhalation chamber.