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EC number: 918-481-9
CAS number: -
MRD-89-582 was examined for its potential to
induce chromosomal damage in bone marrow erythrocytes in mice dosed by
oral gavage at concentrations of 5.0,2.5, and 1.25 g/kg. Vehicle and
positive control animals received corn oil and cyclophosphamide,
respectively. Bone marrow samples were collected and
evaluated for micronucleus formation 24, 48 and 72 hours after dosing.
MRD-89-582 did not induce a statistically significant change in
the PCE/NCE ratio in any of the test material dose groups when compared
to their concurrent vehicle control groups. The positive control
material (cyclophosphamide) produced a marked increase in the frequency
of micronucleated PCE when compared to the concurrent vehicle control
group The test material was considered to be non-genotoxic and
non-clastogenic under the conditions of the test. This finding does not
warrant the classification of the test material as a genotoxin under EU
GHS guidelines and does not warrant classification under the EU
requirements for dangerous substances and preparations guidelines.
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