Hydrocarbons, C10-C13, n-alkanes, isoalkanes, cyclics, < 2% aromatics

Long-term toxicity to aquatic invertebrates

Link to relevant study record(s)

Reference

Endpoint:

long-term toxicity to aquatic invertebrates

Type of information:

(Q)SAR

Adequacy of study:

key study

Study period:

Not applicable, calculated value

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: This summary has a reliability of 2 because the results are estimated using a computer model that is appropriate for use with this hydrocarbon substance.

Justification for type of information:

The aquatic toxicity was estimated by a QSAR, the Petrotox computer model. This model combines a partitioning model used to calculate the aqueous concentration of hydrocarbon components with the Target Lipid Model used to calculate acute and chronic toxicity of non-polar narcotic chemicals. Petrotox computes toxicity based on the summation of the aqueous-phase concentrations of hydrocarbon block(s) that represent a hydrocarbon substance and membrane-water partition coefficients (KMW) that describe the partitioning of the hydrocarbons between the water and organism.

Qualifier:

no guideline followed

Principles of method if other than guideline:

The aquatic toxicity was estimated by a QSAR, the Petrotox computer model. This model combines a partitioning model used to calculate the aqueous concentration of hydrocarbon components with the Target Lipid Model used to calculate acute and chronic toxicity of non-polar narcotic chemicals. Petrotox computes toxicity based on the summation of the aqueous-phase concentrations of hydrocarbon block(s) that represent a hydrocarbon substance and membrane-water partition coefficients (KMW) that describe the partitioning of the hydrocarbons between the water and organism.

GLP compliance:

no

Remarks:

The data were calculated by a computer model

Analytical monitoring:

not required

Vehicle:

no

Test organisms (species):

Daphnia magna

Test type:

other: QSAR modeled data

Water media type:

freshwater

Limit test:

no

Total exposure duration:

21 d

Key result

Duration:

21 d

Dose descriptor:

NOELR

Effect conc.:

0.176 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

reproduction

Validity criteria fulfilled:

yes

Conclusions:

The hydrocarbons, C10-C13, n-alkanes, isoalkanes, cyclics, <2% aromatics, estimated freshwater invertebrate 21-day NOELR (No Observed Effect Loading Rate) value is 0.176 mg/l based on reproduction.

Executive summary:

The aquatic toxicity was estimated using the Petrotox computer model, which combines a partitioning model used to calculate the aqueous concentration of hydrocarbon components as a function of substance loading with the Target Lipid Model used to calculate acute and chronic toxicity of non-polar narcotic chemicals. Petrotox computes toxicity based on the summation of the aqueous-phase concentrations of hydrocarbon block(s) that represent a hydrocarbon substance and membrane-water partitioning coefficients (K_MW) that describe the partitioning of the hydrocarbons between the water and organism. The hydrocarbons, C10-C13, n-alkanes, isoalkanes, cyclics, <2% aromatics, estimated freshwater invertebrate 21-day NOELR (No Observed Effect Loading Rate) value is 0.176 mg/l based on reproduction.

Description of key information

The hydrocarbons, C10-C13, n-alkanes, isoalkanes, cyclics, <2% aromatics, estimated freshwater invertebrate 21-day NOELR (No Observed Effect Loading Rate) value is 0.176 mg/l based on reproduction.

Additional information

The hydrocarbons, C10-C13, n-alkanes, isoalkanes, cyclics, <2% aromatics, estimated freshwater invertebrate 21-day NOELR (No Observed Effect Loading Rate) value is 0.176 mg/l based on reproduction.