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EC number: 219-784-2 | CAS number: 2530-83-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Repeated dose toxicity: dermal
Administrative data
- Endpoint:
- short-term repeated dose toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- significant methodological deficiencies
- Remarks:
- The study did not meet current requirements for repeated dermal toxicity testing, particularly in respect of the number and duration of exposures.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 975
- Report date:
- 1975
Materials and methods
- GLP compliance:
- no
Test material
- Reference substance name:
- [3-(2,3-epoxypropoxy)propyl]trimethoxysilane
- EC Number:
- 219-784-2
- EC Name:
- [3-(2,3-epoxypropoxy)propyl]trimethoxysilane
- Cas Number:
- 2530-83-8
- Molecular formula:
- C9H20O5Si
- IUPAC Name:
- trimethoxy[3-(oxiran-2-ylmethoxy)propyl]silane
- Details on test material:
- 3-Glycidoxypropyltrimethoxysilane (TMSPGE, CAS No.
2530-83-8)
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: other
- Sex:
- male
Administration / exposure
- Details on exposure:
- Route of Administration: dermal
- Duration of treatment / exposure:
- Approximately 1.25 hours/day
- Frequency of treatment:
- Two days (W, F) for the first week, three days (M, W, F) for the second week, and two days (M, W) for the third week for a total of 7 applications over 17 days
Doses / concentrations
- Dose / conc.:
- 1 other: ml/kg
- Control animals:
- yes
- Details on study design:
- Post-exposure period: Not applicable.
Results and discussion
Effect levels
- Dose descriptor:
- NOAEL
- Effect level:
- > 1 other: ml/kg bw
- Based on:
- test mat.
- Sex:
- male
- Basis for effect level:
- other: No adverse effects observed.
Target system / organ toxicity
- Critical effects observed:
- no
Any other information on results incl. tables
There was no mortality or remarkable differences in body
weight or absolute/relative liver or kidney weights.
Abnormal skin responses (desquamation, and fissures) were
noted on the test substance-treated rabbits. No abnormal
skin responses were noted on the control animals.
Applicant's summary and conclusion
- Conclusions:
- The no-observed-effect-level (NOEL) for systemic effects was
determined to be greater than 1.0 mL/kg/application of the
test substance to rabbits under the conditions employed in
this study.
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