Registration Dossier

Administrative data

Endpoint:
basic toxicokinetics
Type of information:
other: Assessment of the toxicokinetic behaviour as can be derived from the available information.
Adequacy of study:
weight of evidence
Cross-reference
Reason / purpose for cross-reference:
reference to same study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2010
Report date:
2010

Materials and methods

Principles of method if other than guideline:
Review of reports summarised in the dataset

Test material

Constituent 1
Chemical structure
Reference substance name:
Propylidynetrimethanol, ethoxylated
EC Number:
500-110-3
EC Name:
Propylidynetrimethanol, ethoxylated
Cas Number:
50586-59-9
Molecular formula:
C3H5(CH2O(C2H4O)nH) sum of n: >1 - <6.5 mol EO
IUPAC Name:
Propylidynetrimethanol, ethoxylated

Results and discussion

Toxicokinetic / pharmacokinetic studies

Details on absorption:
"Because of the vapour pressure and water solubility of the commercial material, some of the lower molecular weight components of the substance are likely to be absorbed via the lung if inhaled.

Based on read across from pentaerythritol and nitrilotriethanol, it is likely that propylidyne trimethanol is absorbed when administered orally. Ethane-1,2-diol, oxydiethanol and (ethylenedioxy)diethanol are also well absorbed, probably by passive diffusion, when administered orally. Thus it is likely that the smaller polyols may be absorbed.

Given the measured logP and water solubility, dermal absorption is likely."


Details on distribution in tissues:
"Given the logP values, it is likely that oligomers of propylidynetrimethanol, ethoxylated will be widely distributed in body water and it is unlikely that they will accumulate in tissues."
Details on excretion:
"The NLP and metabolites are likely to be excreted in urine. Carbon dioxide, if formed, will be exhaled."

Metabolite characterisation studies

Details on metabolites:
"Based on information from ethane-1,2-diol, oxydiethanol and (ethylenedioxy)diethanol, it is likely that the majority of absorbed material will be excreted unchanged, with some oxidation of one or both of the terminal alcohol groups to the corresponding mono and di-acetic acids. Oxalic acid does not appear to be a metabolic product of the (ethylenedioxy)diethanol . At low doses some further metabolism to carbon dioxide may occur. Based on read across from pentaerythritol and nitrilotriethanol, it is likely that any propylidyne trimethanol released will be excreted unchanged in the urine."

Any other information on results incl. tables

"There are no experimental studies on the toxicokinetics of ethoxylated propylidyne trimethanol. The toxicokinetics of ethoxylated propylidyne trimethanol is inferred from the core substance and ethane-1,2-diol, oxydiethanol and (ethylenedioxy)diethanol. The toxicokinetics for these substances are summarised in Illing and Barratt (2007 revised 2009). Propylidyne trimethanol has three free hydroxy groups, thus NLP polyols are likely to consist predominantly of chains of between one and two repeating units, with some chains containing three repeating units. Commercial material contains a range of propoxylated propanediols."

Applicant's summary and conclusion