Registration Dossier
Registration Dossier
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EC number: 249-079-5 | CAS number: 28553-12-0
Endpoint summary
Administrative data
Description of key information
Additional information
DINP has a low potential to bioaccumulate in the environment based on results from a biomagnification food-web field study, a bioaccumulation dietary lab study with a fish, and a measured biota-soil accumulation factor (BSAF) for a soil-dwelling invertebrate. An aquatic food-web study that included 18 marine species, showed that DINP did not biomagnify, but rather decreased in tissue concentration in organisms of increasing trophic position. Decreasing concentrations, also referred to as biodilution, can be quantified by food-web magnification factors (FWMFs). The FWMF for DINP was 0.46. A FWMF that is greater than 1.0 is an indication of chemical biomagnification within a food-web, whereas a value of less than 1.0 indicates biodilution or dilution from lower to higher trophic levels. The FWMF is consistent with a laboratory fish bioaccumulation study in which rainbow trout were fed a DINP spiked diet for 14 days. Results demonstrated limited bioaccumulation with a lipid normalized biomagnification factor (BMF, concentration ratio in tissue to that in diet) of 0.1 and rapid subsequent depuration with a tissue elimination half-life of 1 day. The half-life of 1 day was used to calculate a BCF in fish of <3 L/kg for DINP. Data to assess the potential for terrestrial bioaccumulation of DINP were reported in a 14-day earthworm toxicity study. The BSAF as measured in a natural soil was 0.018. A BSAF value of <1 indicates a lack of bioaccumulation.
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