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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Sensitisation data (human)

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Administrative data

Endpoint:
sensitisation data (humans)
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: abstract

Data source

Reference
Reference Type:
publication
Title:
"Hyperactive cough" in occupational medicine
Author:
Alt, E.; Diller, W.;
Year:
1988
Bibliographic source:
Zbl. Arbeitsmeth., Vol 38, suppl. 2, p.22 - 26

Materials and methods

Type of sensitisation studied:
respiratory
Study type:
case report
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2,4,6-trichloro-1,3,5-triazine
EC Number:
203-614-9
EC Name:
2,4,6-trichloro-1,3,5-triazine
Cas Number:
108-77-0
Molecular formula:
C3Cl3N3
IUPAC Name:
trichloro-1,3,5-triazine
Test material form:
solid: particulate/powder
Remarks:
migrated information: powder

Method

Type of population:
occupational
Ethical approval:
not specified
Subjects:
- one test engineer, non-smoker, 47 years, only occasionally patrolling the production plant for 2,4,6-trichloro-1,3,5-triazine
- no memorable direct exposure with 2,4,6-trichloro-1,3,5-triazine
Clinical history:
- allergic exanthem against Aspirin
- after a infection with fever a dry cough remained
Controls:
not applicable
Route of administration:
inhalation
Details on study design:
- auscultation
- lung function test
- bronchoscopy
- acetylcholine provocation test
- RAST (radioallergosorbent test) for 2,4,6-trichloro-1,3,5-triazine

Results and discussion

Results of examinations:
- auscultation: normal
- lung function test: normal but slightly raised residual volume
- bronchoscopy: one site of inflammatory swelling
- acetylcholine provocation test: no resistance increase but strong urge to cough
- RAST (radioallergosorbent test) for 2,4,6-trichloro-1,3,5-triazine: positive

- complete decay of the dry cough after shifting the person to a different production plant

Applicant's summary and conclusion

Conclusions:
In the present case study a non smoking 47 year old engineer with a dry cough, working occasionally at a 2,4,6-trichloro-1,3,5-triazine production plant, was tested positive for specific IgE against 2,4,6-trichloro-1,3,5-triazine. Dislocation the person from the 2,4,6-trichloro-1,3,5-triazine production plant led to complete decay of the dry cough.