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EC number: 203-614-9 | CAS number: 108-77-0
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Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Type of information:
- other: report on accidential exposure
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: - Documentation insufficient for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- SU DI UN CASO DI INTOSSIGAZIONE ACUTA PROFESSIONALE DA 2-4-6 TRICLORO-1-TRIAZINA (CLORURO DI CIANURILE)
- Author:
- Catenacci, G
- Year:
- 1 987
- Bibliographic source:
- Le medicina del lacoro, 1987,78:2; 155-161
Materials and methods
- Study type:
- poisoning incident
- Endpoint addressed:
- acute toxicity: inhalation
- acute toxicity: dermal
- eye irritation
- GLP compliance:
- no
Test material
- Reference substance name:
- 2,4,6-trichloro-1,3,5-triazine
- EC Number:
- 203-614-9
- EC Name:
- 2,4,6-trichloro-1,3,5-triazine
- Cas Number:
- 108-77-0
- Molecular formula:
- C3Cl3N3
- IUPAC Name:
- trichloro-1,3,5-triazine
Constituent 1
Method
- Type of population:
- occupational
- Subjects:
- - Number of subjects exposed: 1
- Sex: male
- Age: 54
- Race: caucassian
- Demographic information: not applicable
- Known diseases: generally healthy - Ethical approval:
- not specified
- Route of exposure:
- dermal
- inhalation
- ocular
- Reason of exposure:
- accidental
- Exposure assessment:
- not specified
- Details on exposure:
- Cyanuric chloride (one of the basic materials) was accidentally released, because a vessel got broken. The man was totally submerged under the powder.
- Examinations:
- - ECG 1 day and 10 days post exposure
- Urine analysis: not reported
- Haematology: yes, but not described in detail
- Lung function parameters: respirometry (6 times within 4 weeks after the exposure and once 6 months after exposure), oxygen and carbon dioxide concentrations in the blood, blood pH (8 times within 4 weeks after the exposure and once 6 months after exposure)
- analysis of skin and conjunctiva
- auscultation of the lungs and hearts
- palpitation of abdomen, thorax and lymph nodes - Medical treatment:
- - rinsing of the eyes with physiological solution, further not specified treatment of the eyes
- administration of oxygen in the first night after exposure
- treatment with antibiotics and corticoids, mucolytics and teofilin
Results and discussion
- Clinical signs:
- Signs of intoxication consisted of irritation of the skin, eyes and pharynx, followed by serious obstructive pulmonary syndrome with impairment of alveolar capillary exchanges. No effects on the heart function was seen (although a slightly abnormal ECG was reported from an pre-exposure investigation).
- Results of examinations:
- - Urine analysis: not reported
- Haematology: leucocytosis (neutrophils), one day post exposure
- Lung function parameters: marked reduction of the vital capacity until 11 days post exposure, reduction of blood oxygen concentration and rise of carbon dioxide concentration until 7 days after exposure, no effects on blood pH.
- slightly abnormal respiratory sounds in the first time after exposure, viscous mucous in the respiratory tract. - Outcome of incidence:
- The man recovered within 20 days.
Applicant's summary and conclusion
- Conclusions:
- The author reported the occures of irritation to the skin, eyes and pharynx followed later by a serious obstructive pulmonary syndrome with impairment of alveolar-capillary exchanges in case of acute occupational intoxication that occured accidentally in a plant producing herbicides. The patient fully recovered from the skin, eye and lung disorders in three weeks. Due to the insufficient documentation an assessment of the results is not possible.
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