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Toxicological information

Basic toxicokinetics

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Administrative data

Endpoint:
basic toxicokinetics
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
secondary literature
Remarks:
Unpublished data cited from a peer reviewed publication

Data source

Reference
Reference Type:
secondary source
Title:
Enzymatic hydrolysis of carbomethoxy compounds
Author:
Rauenbusch E
Year:
1974
Bibliographic source:
Unpublished report from Bayer AG, Wuppertal, Germany. Cited in: JEFCA Monograph for Dimethyldicarbonate (DMDC). WHO, Geneva

Materials and methods

Test material

Constituent 1
Chemical structure
Reference substance name:
Dimethyl carbonate
EC Number:
210-478-4
EC Name:
Dimethyl carbonate
Cas Number:
616-38-6
Molecular formula:
C3H6O3
IUPAC Name:
dimethyl carbonate

Results and discussion

Applicant's summary and conclusion

Conclusions:
The incubation of dimethyl carbonate with liver or kidney homogenates of porcine or human origin resulted in hydrolytic decomposition of the substance. Further study details were not reported.
Executive summary:

The incubation of dimethyl carbonate with liver or kidney homogenates of porcine or human origin resulted in hydrolytic decomposition of the substance. Further details of this study were not reported.