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Environmental fate & pathways

Biodegradation in water and sediment: simulation tests

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Description of key information

No data are available on degradation rates in surface water and sediment; therefore, the substance is regarded as P/vP from a precautionary point of view.

Degradation products were predicted using a QSAR model. The relevant degradation products are readily biodegradable.

Key value for chemical safety assessment

Additional information


In Article 13 of Regulation (EC) No 1907/2006, it is laid down that information on intrinsic properties of substances may be generated by means other than tests, provided that the conditions set out in Annex XI (of the same Regulation) are met.

According to Annex XI of Regulation (EC) No 1907/2006 (Q)SAR results can be used if (1) the scientific validity of the (Q)SAR model has been established, (2) the substance falls within the applicability domain of the (Q)SAR model, (3) the results are adequate for the purpose of classification and labeling and/or risk assessment and (4) adequate and reliable documentation of the applied method is provided.

For the assessment of the substance, (Q)SAR results were used for the prediction of potential degradation products. The criteria listed in Annex XI of Regulation (EC) No 1907/2006 are considered to be adequately fulfilled and therefore the endpoint(s) sufficiently covered and suitable for risk assessment.

Therefore, experimental simulation testing on sediment and surface water is not provided.


No experimental simulation testing on surface water or sediment has been performed although piperazine is not readily biodegradable. For the persistence assessment, the substance itself is assessed to be P/vP from a precautionary point of view. Potentially forming degradation products have been predicted using a valid QSAR model (CATALOGIC v.5.14.5 BOD 28 days MITI (OECD 301C) v.11.16). The substance is within the applicability domain of the model. The model predicted eight degradation products, of which two can be regarded as relevant based on their predicted quantity (> 0.1%; 2-aminoacetic acid, CAS 56-40-6; oxalonitrile, CAS 460-19-5). These relevant degradation products were evaluated with regard to their biodegradability and bioaccumulation potential based on QSAR data. Both substances were readily biodegradable. Significant accumulation is not to be expected. Thus they are neither PBT, nor vPvB.