Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (sensitising)
Additional information:

Despite of the large amount of toxicological data on carbon tetrachloride, no data were found regarding skin sensitisation in laboratory animals. Therefore, a Lymph Node Assay was performed.

The potential of carbon tetrachloride to induce skin sensitisation was evaluated using the murine Local Lymph Node Assay (LLNA) (Rokh, 2010). The study is quoted Klimisch 1 (compliant to GLP and testing guideline – OECD 429; adequate coherence between data, comments and conclusions). Since the test item was non-irritant in the preliminary test, the highest concentration retained for the main test was the maximum concentration. In the main test, the three concentrations used in the treated groups were 25%, 50% or 100%. A dose-related increase in the SI was noted at all the concentrations (25 %: SI = 1.51; 50 %: SI = 2.39; 100%: SI =6.10) and the threshold of 3 was exceeded at the concentration of 100%.

In the absence of local irritation, the positive lymphoproliferative response observed was attributed to delayed contact hypersensitivity. The EC3 value for carbon tetrachloride was equal to 58%. Therefore, on the basis of a weak relative skin sensitization potency, carbon tetrachloride is classified as skin sensitiser category 1B according to CLP regulation EU No. 286/2011.

Carbon tetrachloride is not known to be a skin sensitiser in humans.

Migrated from Short description of key information:

Based on the results of a well-conducted LLNA test in mouse, carbon tetrachloride is classified as a weak sensitiser.

Respiratory sensitisation

Endpoint conclusion
Additional information:

Migrated from Short description of key information:

There are no data.

Justification for classification or non-classification

The substance is classified as skin sensitiser according to EU directive 67/548/EEC and skin sensitiser category 1B according to CLP regulation EU No 286/2011.