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EC number: 200-262-8
CAS number: 56-23-5
The potential of the test substance CTC (carbon tetrachloride) to induce
toxicity upon exposure via the oral route was evaluated in a survey
study on different substances following generally OECD TG 401. The scope
of the study was to evaluate a new strategy to determine LD50 values
with a lower amount of animals. Nevertheless the total amount of tested
animals in each dose group allowed for CTC a classical determination of
a LD50 value according to OECD TG 401. Male rats (unspecified strain)
were treated at a single oral dose bw with CTC (unknown vehicle).
Observation period was 14 d and further experimental details were not
reported but stated to be conducted according to OECD TG 401.
The mortality incidences were 0/11 at 1500 mg/kg bw, 5/11 at 2000 mg/kg,
6/11 at 2800 mg/kg and 11/11 at 3900 mg/kg.
The LD 50(rat, oral) was therefore assessed to be 2500 mg/kg bw after
single oral application via gavage.
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