Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 273-776-3 | CAS number: 69012-79-9 Product of the reaction of zinc ore concentrates with air at 954°C to 1010°C (1750°F to 1850°F). Consists primarily of ZnO, ZnFeO2, ZnSO4 and a composite of metallic oxides.
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- calculation (if not (Q)SAR)
- Remarks:
- Migrated phrase: estimated by calculation
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- accepted calculation method
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- other: software
- Title:
- Unnamed
- Year:
- 2 018
Materials and methods
- Principles of method if other than guideline:
- Acute oral toxicity potential of the UVCB substance was determined by classifying based on Mixture rules from EU CLP (additivity formula of classified components to derive hazard class) and back calculation to the corresponding acute toxicity range estimate.
- GLP compliance:
- not specified
- Remarks:
- no GLP necessary for calculation method
Test material
- Reference substance name:
- Calcines, zinc ore-conc.
- EC Number:
- 273-776-3
- EC Name:
- Calcines, zinc ore-conc.
- Cas Number:
- 69012-79-9
- Molecular formula:
- Not available, UVCB substance.
- IUPAC Name:
- Product of the reaction of zinc ore concentrates with air at high temperature, consisting mainly of ZnO, ZnFeO2, a composite of metallic oxides and some residual sulfides and sulphates.
- Test material form:
- solid: bulk
- Details on test material:
- The substance was tested as powder.
Constituent 1
Results and discussion
Effect levels
- Dose descriptor:
- other: acute toxicity estimate ATE
- Effect level:
- > 300 - <= 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- not measured/tested
- Remarks:
- Based on MeClas calculation
Any other information on results incl. tables
According to MeClas, the substance is classified as Acute toxicity Oral Category 4 - H302.
Based on this result, the related criteria provided the estimated value for acute toxicity-oral (Acute Toxicity Point Estimate) (see EU CLP Guidance Annex I Table 3.1.2): 500 mg/kg bodyweight.
Applicant's summary and conclusion
- Conclusions:
- Good quality estimate of the Acute Toxicity Estimate (ATE) -oral of the UVCB substance.
The substance is classified as acute toxic resulting in an ATE of 500 mg/kg bodyweight. - Executive summary:
The study provided a conservative estimate of the effect concentration, derived on basis of the classification outcome (mixture toxicity rules) from a reasonable worst-case sample of the substance using mineralogical information from the representative sample.
Validity of the model used:
1. Defined endpoint: the endpoint is a REACH compliant defined endpoint
2. Unambiguous algorithm: EU CLP guidance based summation formula to determine classification, followed by back-calculation to related hazard criteria
3. Applicability domain: applicable to classify complex metal containing materials.
4. Mechanistic interpretation - metal species: the tool translates the elemental composition into a mineralogical composition relevant for classification.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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