Registration Dossier
Registration Dossier
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EC number: 203-962-1 | CAS number: 112-35-6
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Scientifically reliable study.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 989
- Report date:
- 1989
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Principles of method if other than guideline:
- No further information available.
- GLP compliance:
- yes
Test material
- Reference substance name:
- 2-(2-(2-methoxyethoxy)ethoxy)ethanol
- EC Number:
- 203-962-1
- EC Name:
- 2-(2-(2-methoxyethoxy)ethoxy)ethanol
- Cas Number:
- 112-35-6
- Molecular formula:
- C7H16O4
- IUPAC Name:
- 2-[2-(2-methoxyethoxy)ethoxy]ethan-1-ol
- Reference substance name:
- Triethylene glycol monomethyl ether
- IUPAC Name:
- Triethylene glycol monomethyl ether
- Details on test material:
- No further information available.
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: 3 - 5 months
- Weight at study initiation: 2.5 - 2.6 kg
- Housing: In individual cages in air-conditioned spaces (Battery cages
- Diet: Altromin 2123 Haltungsdilt - rabbits Altromin GmbH Lage / Lippe, ad llbitum and hay (about 15g)
- Water: deionized water ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature: 20±3 °C
- Humidity: 50 +/-20 %
- Photoperiod: 12 hours a day
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- not specified
- Vehicle:
- not specified
- Controls:
- not specified
- Amount / concentration applied:
- Dorsal area
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- No further information available.
- Number of animals:
- 3
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
Any other information on results incl. tables
| Time after removal of patch | 30 - 60 minutes | 24 hours | 48 hours | 72 hours |
| Animal number | 1, 2 & 3 | 1, 2 & 3 | 1, 2 & 3 | 1, 2 & 3 |
| Erythema and eschar | 0, 0, 0 | 0, 0, 0 | 0, 0, 0 | 0, 0, 0 |
| Edema | 0, 0, 0 | 0, 0, 0 | 0, 0, 0 | 0, 0, 0 |
Applicant's summary and conclusion
- Interpretation of results:
- no data
- Remarks:
- Migrated information Criteria used for interpretation of results: not specified
- Executive summary:
In a well reported guideline study skin irritation study, no effect were seen with the substance 2 -(2 -(2 -methoxyethoxy)ethoxy)ethanol.
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