Registration Dossier
Registration Dossier
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EC number: 617-969-6 | CAS number: 87135-01-1
Endpoint summary
Administrative data
Description of key information
In an in vivo skin irritation study conducted according to OECD 404 and in compliance with GLP, 1,6-bis(trimethoxysilyl)hexane was not irritating to rabbit skin (Dow Corning Corporation, 2009a).
In an in vivo eye irritation study conducted according to OECD 405 and in compliance with GLP, 1,6-bis(trimethoxysilyl)hexane was not irritating to rabbit eyes (Dow Corning Corporation, 2009b).
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
In an in vivo skin irritation study conducted according to OECD 404 and in compliance with GLP, 1,6-bis(trimethoxysilyl)hexane was not irritating to rabbit skin (Dow Corning Corporation, 2009a). 0.5 ml of neat test material was applied to the intact skin of 3 animals for 4 hours under a semi-occlusive dressing. No signs of dermal irritation or corrosion were seen at any scoring interval throughout the study on any animal
In an in vivo eye irritation study conducted according to OECD 405 and in compliance with GLP, 1,6-bis(trimethoxysilyl)hexane was not irritating to rabbit eyes (Dow Corning Corporation, 2009b). 0.1 ml of neat test material was instilled in the conjunctival sac of 3 animals. Redness and chemosis were noted in one animal, and redness only was noted in another animal at the 1 hour observation. There were no observations indicating irritation or corrosion at 24 h, 48 h or 72 h post-instillation.
Justification for selection of skin irritation / corrosion endpoint:
The selected study is the only available skin irritation test for this substance. It was conducted in accordance with an appropriate OECD test guideline and in compliance with GLP.
Justification for selection of eye irritation endpoint:
The selected study is the only available eye irritation test for this substance. It was conducted in accordance with an appropriate OECD test guideline and in compliance with GLP.
Justification for classification or non-classification
Based on the available in vivo skin and eye irritation studies, the substance is not classified as irritant or corrosive according to Regulation (EC) No 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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