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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Short-term toxicity to aquatic invertebrates

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Administrative data

Link to relevant study record(s)

Description of key information

Daphnia magna. 48hr EC50 =27,000mg/l (protocol: ISO6341)
Daphnia magna. 24hr EC50 >10,000mg/l (protocol: no data)
Daphnia magna. 24hr EC50 >10,000mg/l (protocol: no data)
Daphnia magna. 24hr TLm >10,000mg/l (protocol: no data)
Rotifer (Brachionus sp.) 48hr EC50 (reproduction) = 9400mg/l (protocol: AFNOR)
Oyster (Crassostrea sp.) 24hr NOEC (developmental toxicity) >1000mg/l
Daphnia magna. 48hr EC50 =7770mg/l (protocol: QSAR)
Mysid. 48hr EC50 =168,000mg/l (protocol: QSAR)

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates
Effect concentration:
9 400 mg/L

Marine water invertebrates

Marine water invertebrates
Effect concentration:
10 000 mg/L

Additional information

A number of studies have been carried out using multiple species, both fresh and salt water. These indicate that methoxyethanol is practically non-toxic to invertebrates. Some of these were not performed for the normally required 48hrs (only 24hr studies) however one study was for the requisite period and to a modern protocol. In addition, modelling ( 48hr QSAR) predictions also confirm that methoxyethanol is practically non toxic to both fresh and saltwater invertebrates. In another 48 hour acute toxicity study, rotifers showed a reduction in reproduction rate from concentrations of ~450mg/l upwards. However, the results showed a very shallow dose response curve and wide confidence intervals and should to be used with caution. In a study in oyster larvae, there was no evidence of developmental effects after 24hrs exposure to concentrations up to 1000mg/l. The result for the rotifer is the lowest EC50 value available and is used to derive the EC50 for this trophic level.