Registration Dossier
Registration Dossier
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EC number: 203-713-7 | CAS number: 109-86-4
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
Daphnia magna. 48hr EC50 =27,000mg/l (protocol: ISO6341)
Daphnia magna. 24hr EC50 >10,000mg/l (protocol: no data)
Daphnia magna. 24hr EC50 >10,000mg/l (protocol: no data)
Daphnia magna. 24hr TLm >10,000mg/l (protocol: no data)
Rotifer (Brachionus sp.) 48hr EC50 (reproduction) = 9400mg/l (protocol: AFNOR)
Oyster (Crassostrea sp.) 24hr NOEC (developmental toxicity) >1000mg/l
Daphnia magna. 48hr EC50 =7770mg/l (protocol: QSAR)
Mysid. 48hr EC50 =168,000mg/l (protocol: QSAR)
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 9 400 mg/L
Marine water invertebrates
Marine water invertebrates
- Effect concentration:
- 10 000 mg/L
Additional information
A number of studies have been carried out using multiple species, both fresh and salt water. These indicate that methoxyethanol is practically non-toxic to invertebrates. Some of these were not performed for the normally required 48hrs (only 24hr studies) however one study was for the requisite period and to a modern protocol. In addition, modelling ( 48hr QSAR) predictions also confirm that methoxyethanol is practically non toxic to both fresh and saltwater invertebrates. In another 48 hour acute toxicity study, rotifers showed a reduction in reproduction rate from concentrations of ~450mg/l upwards. However, the results showed a very shallow dose response curve and wide confidence intervals and should to be used with caution. In a study in oyster larvae, there was no evidence of developmental effects after 24hrs exposure to concentrations up to 1000mg/l. The result for the rotifer is the lowest EC50 value available and is used to derive the EC50 for this trophic level.
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