Registration Dossier
Registration Dossier
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EC number: 231-150-7 | CAS number: 7440-41-7
Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Type of information:
- other: Case report (insurance)
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Information on a single patient, only diagnoses and exposure estimates given
Data source
Reference
- Reference Type:
- publication
- Title:
- Lung tumours by using beryllium containing tools? (Lungentumor durch die Bearbeitung berylliumhaltiger Werkzeuge?)
- Author:
- Kampen V. van, J.Buenger, R. Merget, Bruening T.
- Year:
- 2 008
- Bibliographic source:
- BGFA-Info 02/08, 6 - 9, (2008) Forschungsinstitut für Arbeitsmedizin der Deutschen Gesetzlichen Unfallversicherung
Materials and methods
- Study type:
- clinical case study
- Endpoint addressed:
- carcinogenicity
Test material
- Reference substance name:
- Beryllium
- EC Number:
- 231-150-7
- EC Name:
- Beryllium
- Cas Number:
- 7440-41-7
- Molecular formula:
- Be
- IUPAC Name:
- beryllium
Constituent 1
Method
- Subjects:
- Human male, 60 - 70 years old.
- Route of exposure:
- inhalation
- Reason of exposure:
- unintentional, occupational
- Exposure assessment:
- estimated
Results and discussion
- Clinical signs:
- Not given. Chemotherpy with little effect. Brain metastase treated by radiation.
Any other information on results incl. tables
The history of the patient does not report any incident of acute beyllium disease.
Potenial causal exposures:
Asbestos: 0.8 "fibre years"
Be containing dusts (max. 2 %): 0.5 h/week over 18 years
Smoking: 63 - 100 "package years"
Applicant's summary and conclusion
- Conclusions:
- The BGFA accepts beryllium as cause for lung tumors only if the person has suffered from an acute beryllium disease before.
- Executive summary:
The case of a former airplane mechanic with an adenocarcinoma T2 NX M1 (BRA), Stadium IV is discussed with regard to his professional exposure beryllium containing dusts. The exposure was deemed low and as there is no acute beryllium disease on record, the causality of beryllium was denied. Smoking is considered as cause.
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