Ethylene carbonate

Repeated dose toxicity: inhalation

Administrative data

Endpoint:

sub-chronic toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: Study results summarized in inter-office correspondence. Insufficient experimental details provided to assess reliability.

Data source

Reference

Reference Type:

other: Inter-office correspondence

Title:

Unnamed

Year:

1953

Report date:

1953

Materials and methods

Test guideline

Qualifier:

no guideline followed

GLP compliance:

no

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Ethylene carbonate

EC Number:

202-510-0

EC Name:

Ethylene carbonate

Cas Number:

96-49-1

Molecular formula:

C3H4O3

IUPAC Name:

1,3-dioxolan-2-one

Test material form:

solid: crystalline

Details on test material:

- Name of test material (as cited in study report): Ethylene carbonate
- Purity: > 99%
- Physical state: fine crystals

Test animals

Species:

other: dogs, guinea pigs and rats

Strain:

not specified

Sex:

not specified

Administration / exposure

Route of administration:

inhalation: aerosol

Type of inhalation exposure:

not specified

Vehicle:

other: no data

Details on inhalation exposure:

-Administered as an aerosol

Analytical verification of doses or concentrations:

yes

Details on analytical verification of doses or concentrations:

No data

Duration of treatment / exposure:

32 days

Frequency of treatment:

5 days/week over a period of 32 days

Doses / concentrations

Doses / concentrations 1

Dose / conc.:

8 ppm (analytical)

Remarks:

for the first 9 days of the experiment

Doses / concentrations 2

Dose / conc.:

110 ppm (analytical)

Remarks:

for the remainder of the experiment

No. of animals per sex per dose:

2 dogs, 7 guinea pigs, 7 rats; sex not specified

Control animals:

not specified

Positive control:

No data

Examinations

Observations and examinations performed and frequency:

CAGE SIDE OBSERVATIONS: Yes
- Time schedule: No data

HAEMATOLOGY: Yes, dogs only
- Time schedule for collection of blood: Routine samples performed at intervals and at the end of the experiment for the dogs

URINALYSIS: Yes, dogs only
- Time schedule for collection of urine: End of experiment for dogs.

Sacrifice and pathology:

- At experiment termination, gross and microscopic pathology evaluated

Results and discussion

Results of examinations

Clinical signs:

no effects observed

Mortality:

no mortality observed

Body weight and weight changes:

not examined

Food consumption and compound intake (if feeding study):

not examined

Food efficiency:

not examined

Water consumption and compound intake (if drinking water study):

not examined

Ophthalmological findings:

not examined

Haematological findings:

no effects observed

Clinical biochemistry findings:

not examined

Urinalysis findings:

no effects observed

Behaviour (functional findings):

not examined

Organ weight findings including organ / body weight ratios:

not examined

Gross pathological findings:

no effects observed

Histopathological findings: non-neoplastic:

effects observed, treatment-related

Histopathological findings: neoplastic:

not examined

Details on results:

CLINICAL SIGNS AND MORTALITY: No signs of toxicity were noted in any of the animals during the course of the study.

HISTOPATHOLOGY: NON-NEOPLASTIC: Microscopically, mild interstitial irritation was observed in the lungs.

Target system / organ toxicity

Critical effects observed:

not specified

Applicant's summary and conclusion

Conclusions:

Under the conditions of this study, there were no signs of toxicity and microscopically only mild interstitial irritation was observed in the lungs of dogs, guinea pigs, and rats exposed to aerosolized test substance.