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EC number: 202-510-0 | CAS number: 96-49-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- February 15-19,2000
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Study was performed according to following guidelines: OECD 404, EU Method B.4, EPA OPPTS 870.2500 and in compliance with to the GLP Regulations. No significant deviations can be observed from the study guidelines, which could have an impact on the performed study.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 001
- Report date:
- 2001
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- stability not reported
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.2500 (Acute Dermal Irritation)
- Principles of method if other than guideline:
- 26% humidity was recorded: this is slightly outside the range specified in the study protocol. This deviation was not considered to have affected the integrity or validity of the study.
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Ethylene carbonate
- EC Number:
- 202-510-0
- EC Name:
- Ethylene carbonate
- Cas Number:
- 96-49-1
- Molecular formula:
- C3H4O3
- IUPAC Name:
- 1,3-dioxolan-2-one
- Test material form:
- solid: crystalline
- Details on test material:
- - Name of test material (as cited in study report): Ethylene carbonate
- Purity: > 99%
- Physical state: fine crystals
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Harlan UK Ltd, Bicester, Oxon, England.
- Age at study initiation: at least 11 weeks old (adult)
- Weight at study initiation: 2.3-2.4 kg
- Housing: individually in stainless steel cages with perforated floors in Building R17 Room 10.
- Diet (e.g. ad libitum): a standard laboratory rabbit diet (Special Diet Services STANRAB (P) SQC pellet), ad libitum
- Water (e.g. ad libitum): potable water ( Anglian) for human consumption, ad libitum.
- Acclimation period: min.5d
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20-20.5°C
- Humidity (%): 26-36 %
- Photoperiod (hrs dark / hrs light): 12h dark/12h light
IN-LIFE DATES: From: 15 Feb 2000 To: 19 Feb 2000
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: OECD 404: untreated area of the test animal serves as control
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 ml - Duration of treatment / exposure:
- -3min, 1h, 4h
- Observation period:
- 4d
- Number of animals:
- 3
- Details on study design:
- TEST SITE
- Area of exposure: app.25 mm x 25 mm, dorso-Iumbar region (clipped free of fur) /
- Type of wrap if used: 2-ply 25mm x 25 mm porous gauze pad, each treatment site was covered with "Elastoplast" elastic adhesive dressing.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): washed with warm water (36 to 37°C)
- Time after start of exposure: 3 min, 1 and 4h
SCORING SYSTEM: observation
Draize Evaluation of Dermal Irritation
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Remarks on result:
- other: 3 min, 1 and 4 h exposure (intact skin), no dermal irritation
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Remarks on result:
- other: 3 min, 1 and 4 h exposure (intact skin), no dermal irritation
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Remarks on result:
- other: 3 min, 1 and 4 h exposure (intact skin), no dermal irritation
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Remarks on result:
- other: 3min, 1 and 4 hours exposure (intact skin), no dermal irritation
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Remarks on result:
- other: 3 min, 1 and 4 h exposure (intact skin), no dermal irritation
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Remarks on result:
- other: 3 min, 1 and 4 h exposure (intact skin), no dermal irritation
- Irritant / corrosive response data:
- There were no signs of toxicity or ill health in any rabbit during the observation period. (on day 1, 2, 3 or 4)
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- A single semi-occlusive application of JEFFSOL Ethylene Carbonate (ultra pure grade) to intact rabbit skin for four hours elicited no dermal irritation.
JEFFSOL Ethylene Carbonate (ultra pure grade) will not require labelling with the risk phrase R38, "Irritating to skin", in accordance with Commission Directive 93/21IEEC.
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