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EC number: 202-510-0 | CAS number: 96-49-1
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable with OECD Guideline 401 with acceptable restrictions (partly limited documentation, e.g. no details on test substance or concentration in vehicle; dose levels not clearly specified, no data on clinical signs or necropsy)
Data source
Reference
- Reference Type:
- publication
- Title:
- Range-finding toxicity data List V
- Author:
- Smith HF, Carpenter CP, Weil CS, Pozzani UC
- Year:
- 1 954
- Bibliographic source:
- J Ind Hyg Occup Med 10: 61-68
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- see rationale for reliability
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Ethylene carbonate
- EC Number:
- 202-510-0
- EC Name:
- Ethylene carbonate
- Cas Number:
- 96-49-1
- Molecular formula:
- C3H4O3
- IUPAC Name:
- 1,3-dioxolan-2-one
- Test material form:
- solid: crystalline
- Details on test material:
- - Name of test material (as cited in study report): Ethylene carbonate
- Purity: > 99%
- Physical state: fine crystals
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Carworth-Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- Source: rats raised in the authors own colony
Diet: Rockland rat diet complete
Initial body weight: 90 to 120 g
Rats not fasted before dosing
No further data
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- No details
- Doses:
- dosages in a logarithmic series (no further data)
- No. of animals per sex per dose:
- Groups of five male rats
- Control animals:
- no
- Details on study design:
- Post exposure observation period 14 days
- Statistics:
- The LD50 value and its fiducial range are estimated by the method of Thompson (Bact. Rev. 11 :115, 1947) using the tables of Weil (Biometrics 8 :249, 1952).
Results and discussion
Effect levels
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 10 400 mg/kg bw
- 95% CL:
- 7 940 - 13 620
- Mortality:
- no further data
- Clinical signs:
- other: no data
- Gross pathology:
- no data
- Other findings:
- no
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In male rats the LD50 is 10400 mg/kg bw.
- Executive summary:
The study is comparable to OECD Guideline 401 with acceptable restrictions (partly limited documentation, e.g. no details on test substance or concentration in vehicle; dose levels not clearly specified, no data on clinical signs or necropsy).
Groups of 5 male Carworth-Wistar rats were gavaged with dosages in a logarithmic series. The post exposure observation period was 14 days. The authors calculated a LD50 value of 10400 mg/kg bw. The test substance is practically non-toxic.
Conclusion: In male rats the LD50 is 10400 mg/kg bw.
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