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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Comparable with OECD Guideline 401 with acceptable restrictions (partly limited documentation, e.g. no details on test substance or concentration in vehicle; dose levels not clearly specified, no data on clinical signs or necropsy)

Data source

Reference
Reference Type:
publication
Title:
Range-finding toxicity data List V
Author:
Smith HF, Carpenter CP, Weil CS, Pozzani UC
Year:
1954
Bibliographic source:
J Ind Hyg Occup Med 10: 61-68

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Deviations:
yes
Remarks:
see rationale for reliability
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Ethylene carbonate
EC Number:
202-510-0
EC Name:
Ethylene carbonate
Cas Number:
96-49-1
Molecular formula:
C3H4O3
IUPAC Name:
1,3-dioxolan-2-one
Test material form:
solid: crystalline
Details on test material:
- Name of test material (as cited in study report): Ethylene carbonate
- Purity: > 99%
- Physical state: fine crystals

Test animals

Species:
rat
Strain:
other: Carworth-Wistar
Sex:
male
Details on test animals or test system and environmental conditions:
Source: rats raised in the authors own colony
Diet: Rockland rat diet complete
Initial body weight: 90 to 120 g
Rats not fasted before dosing
No further data

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
water
Details on oral exposure:
No details
Doses:
dosages in a logarithmic series (no further data)
No. of animals per sex per dose:
Groups of five male rats
Control animals:
no
Details on study design:
Post exposure observation period 14 days
Statistics:
The LD50 value and its fiducial range are estimated by the method of Thompson (Bact. Rev. 11 :115, 1947) using the tables of Weil (Biometrics 8 :249, 1952).

Results and discussion

Effect levels
Key result
Sex:
male
Dose descriptor:
LD50
Effect level:
10 400 mg/kg bw
95% CL:
7 940 - 13 620
Mortality:
no further data
Clinical signs:
other: no data
Gross pathology:
no data
Other findings:
no

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
In male rats the LD50 is 10400 mg/kg bw.
Executive summary:

The study is comparable to OECD Guideline 401 with acceptable restrictions (partly limited documentation, e.g. no details on test substance or concentration in vehicle; dose levels not clearly specified, no data on clinical signs or necropsy).

Groups of 5 male Carworth-Wistar rats were gavaged with dosages in a logarithmic series. The post exposure observation period was 14 days. The authors calculated a LD50 value of 10400 mg/kg bw. The test substance is practically non-toxic.

Conclusion: In male rats the LD50 is 10400 mg/kg bw.