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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
29/11/2009 - 06/12/2009
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
EU Method A.8 (Partition Coefficient)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
shake-flask method to: flask method
Partition coefficient type:
octanol-water
Analytical method:
photometric method
Key result
Type:
log Pow
Partition coefficient:
ca. 0.11
Temp.:
20 °C
pH:
> 5.33 - < 5.79
Details on results:
Vessel 1 (1:1): log Pow = 0.13
Vessel 2 (1:1): log Pow = 0.10
Vessel 3 (2:1): log Pow = -0.19
Vessel 4 (2:1): log Pow = -0.19
Vessel 5 (1:2): log Pow = 0.10
Vessel 6 (1:2): log Pow = 0.09

Due to interference, erroneous results were obtained from analysis of concentration from 2:1 octanol/water ratio. As a results log Pow was calculated using concentrations from the 1:1 and 1:2 ratios.

Conclusions:
The log Pow of ethylene carbonate was concluded to be 0.11 following a GLP study conducted in accordance with EU method A.8, using the shake flask method.

Description of key information

The mean log Pow of ethylene carbonate was calculated to be 0.11 following a GLP study conducted in accordance with EU test method A.8, using the shake flask method (Baker, 2010).

Key value for chemical safety assessment

Log Kow (Log Pow):
0.11
at the temperature of:
20 °C

Additional information