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EC number: 201-039-8 | CAS number: 77-58-7
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Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
A reliability rating of 1 was assigned to the key study provided for this endpoint, according to the criteria of Klimisch, 1997 as the study was conducted in accordance with a recognised guideline and GLP.
Clarke, N (2010) ASSESSMENT OF THE INHIBITORY EFFECT ON THE RESPIRATION OF ACTIVATED SEWAGE SLUDGE. Testing Laboratory: Harlan Laboratories Ltd, Shardlow Business Park, London Road, Shardlow, Derbyshire, DE72 2GD, UK. Owner company: Organo Tin REACH Consortium, c/o ReachCentrum, Avenue E. Van Nieuwenhuyse 6, B-1160, Brussels, BELGIUM. Report No.: 3109/0047. Report date: 2010-07-05
The effect of the test item on the respiration of activated sewage sludge micro-organisms gave a 3-Hour EC50 of greater than 1000 mg/l. The No Observed Effect Concentration (NOEC) after 3 hours exposure was 1000 mg/l.
Supporting information was also available for this endpoint.
Steinhaeuser K.G., Amann W, Spaeth A, & Polenz A (1985) Investigations on the Aquatic Toxicity of Organotin Compounds. Bibliographic source: Vom Wasser. 65:203-214.
The EC50 of Photobacterium phosphoreum based on the inhibition of bioluminescence is 0.570 mg/L (570 ppb).
A reliability rating of 4 was assigned to this study, according to the criteria of Klimisch, 1997 as the study does not give sufficient experimental details and is therefore of reduced reliability.
Key value for chemical safety assessment
- EC10 or NOEC for microorganisms:
- 1 000 mg/L
Additional information
Clarke N (2010) was assigned the key study for this endpoint. The study was performed to the OECD guideline 209 and in compliance with GLP. The study was therefore considered reliable and adequate for assessment. Activated sewage sludge was exposed to an aqueous dispersion of the test item at concentrations of 10, 32, 100, 320 and 1000 mg/l for a period of 3 hours at a temperature of 21 ± 1 °C with the addition of a synthetic sewage as a respiratory substrate. The rate of respiration was determined after 3 hours contact time and compared to data for the control and a reference item, 3,5-dichlorophenol. The effect of the test item on the respiration of activated sewage sludge gave a 3 Hour EC50of greater than 1000 mg/l. The No Observed Effect Concentration (NOEC) after 3 hours exposure was 1000 mg/l. It was considered unnecessary and unrealistic to test at concentrations in excess of 1000 mg/l.
The supporting study Steinhaeuser, K.G et al (1985) was assigned a reliability score of 4. Areas of the reporting lacked detail and it was therefore not possible to determine the reliability of the data available. Determination of the inhibition of bioluminescence of Photobacterium phosphoreum using a Beckman Microtox Photometer.The EC50 ofPhotobacteriumphosphoreumbased on the inhibition of bioluminescence is 0.570 mg/L (570 ppb).
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