Registration Dossier
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EC number: 211-776-7 | CAS number: 694-83-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Study period:
- From 27 AUG 1986 to 29 AUG 1986
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data given: comparable to standards
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 986
- Report Date:
- 1986
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- observation time: only up to 48 h
- GLP compliance:
- not specified
Test material
Reference
- Name:
- Unnamed
- Type:
- Constituent
- Details on test material:
- - Name of test material (as cited in study report): 2-Methylpentamethylenediamine
- Substance type: clear liquid
- Physical state: fluid
- Analytical purity: 98.5 %
- Impurities (identity and concentrations): Ethyltetramethylenediamine
- Stability under test conditions: the test material was assumed to be stable under the conditions of administration
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals and environmental conditions:
- TEST ANIMALS
- Source: Hare Marland, Hewitt, New Jersey, USA
- Age at study initiation: young adult
- Housing: single in suspended, stainless steel, wire-mesh cages
- Diet: Purina certified Rabbit Chow (#5322), ad libitum
- Water, ad libitum
- Acclimation period: not mentioned
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 +/-2
- Humidity (%): 50 +/-10
- Photoperiod (hrs dark / hrs light): 12/12
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- other: clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- 0.5 ml
- Duration of treatment / exposure:
- 3 min
- Observation period:
- 3 min, 24 and 48 h after exposure
- Number of animals:
- 6
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): with warm water
- Time after start of exposure: 3 min
SCORING SYSTEM: According to Draize Scale
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 3 min, 24 and 48 h after application
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24 and 48 h after application
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- not reversible
- Irritant / corrosive response data:
- After 3 min, 24 and 48 h necrosis was visible in all six animals. In the 48 h reading blanching of the skin was also visible.
Edema scores in the 3 min reading were 0 for all animals.
Applicant's summary and conclusion
- Interpretation of results:
- Category 1A (corrosive)
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Under the applied test conditions the test substance induced skin corrosion in all six animals.
- Executive summary:
A skin irritation/corrosion test was performed with six rabbits. The animals were exposed to 0.5 ml of test substance on the clipped skin for 3 minutes. The skin reactions were observed for 48 h after the initial exposure. All six animals showed severe skin corrosion with necrosis and skin blanching. Severe erythema and necrosis already were visible at the first reading time (i.e. 3 minutes).
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