Registration Dossier

Administrative data

Endpoint:
dermal absorption
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Study period:
no data
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Only secondary literature (evaluation and comparison of available data on alipathic amines)
Cross-reference
Reason / purpose:
reference to same study

Data source

Reference
Reference Type:
publication
Title:
Toxicity of aliphatic amines: structure-activity relationship
Author:
Greim H, Bury D, Klimisch H J, Oeben-Negele M, Ziegler-Skylakakis K
Year:
1998
Bibliographic source:
Chemosphere, Volume 36, Issue 2, Pages 271–295

Materials and methods

GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Various aliphatic amines (17 primary, 11 secondary and 9 tertiary amines).

Results and discussion

Any other information on results incl. tables

In general short chained amines (primary and secondary) are absorbed relatively well through the skin. Dermal absorption decreases with increasing chain length (i.e. >= C6).

Applicant's summary and conclusion

Conclusions:
In general short chained amines (primary and secondary) are absorbed relatively well through the skin. Dermal absorption decreases with increasing chain length (i.e. >= C6).