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Toxicological information

Basic toxicokinetics

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Administrative data

Endpoint:
basic toxicokinetics
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Study period:
No data
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Only secondary literature (evaluation and comparison of available data on alipathic amines)
Cross-reference
Reason / purpose:
reference to same study

Data source

Reference
Reference Type:
publication
Title:
Toxicity of aliphatic amines: structure-activity relationship
Author:
Greim H, Bury D, Klimisch H J, Oeben-Negele M, Ziegler-Skylakakis K
Year:
1998
Bibliographic source:
Chemosphere, Volume 36, Issue 2, Pages 271–295

Materials and methods

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Various aliphatic amines (17 primary, 11 secondary and 9 tertiary amines).

Results and discussion

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): no data
After intravenous application of primary aliphatic amines, they were detected in the lung, liver, kidney, heart, spleen and brain. Metabolism found included oxidization via monoamine oxidase to aldehydes, followed by metabolic conversion to carboxylic acids via dehydration. Furthermore beta-oxidation was observed resulting in excretion of CO2. Monoamine oxidase selective binding was reduced with increasing chain length of the amines. Moreover the excretion via CO2 was found to be dependent on the chain lenght, too. Primary amines with C6 were shown to have the highest elimination rate via CO2. The rate diminishes with alterations in chain length (increasing as well as decreasing; <>>). Some amines are excreted mostly unmetabolised in the urine (e.g. ethylamine or diethylamin).