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EC number: 211-776-7 | CAS number: 694-83-7
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
A reliable study on daphnia magna reproduction (according to OECD 211 and compliant to GLP, reliability category 1) with semistatic design and analytical determination of test item concentration resulted in a NOEC (21 d, reproduction) of 4.16 mg/L and an EC50 (21 d, adult mortality) of 6.04 mg/L (time weighted mean measured concentrations).
Key value for chemical safety assessment
- EC10, LC10 or NOEC for freshwater invertebrates:
- 4.16 mg/L
Additional information
A reliable study on daphnia magna reproduction (according to OECD 211 and compliant to GLP, reliability category 1) on the amine heads category member HMD with semi-static test-design (change of test medium 3 times per week) and analytical determination of test item concentration performed by the Japanese Ministry of the Environment (2003) resulted in a NOEC (21 d, reproduction) of 4.16 mg/L and an EC50(21 d, adult mortality) of 6.04 mg/L (time weighted mean measured concentrations).
The concentrations for each test solution were measured 3 times (before and after renewal, total 6 times) during test period using a HPLC/IC. 6 Nominal concentrations between 0.46 and 22 mg/L were tested and the pH was between 7.1 and 9.5 and was not adjusted. No adult mortality occurred in the control and up to and including the nominal test item concentration of 4.6 mg/L (4.16 mean measured) and validity criteria of the guideline were fulfilled. The time to first brood production was 8 days in the control and up to the mean measured test item concentration of 1.93 mg/L. At the time weighted mean measured test item concentration of 4.16 mg/L for 7 test organisms also 8 days to first brood were observed while for three test organisms 10 days are reported. At this concentration the number of offspring was reduced by 7.3% compared to the control, which however was not statistically significant (NOEC). At the next higher test item concentration of nominal 10 mg/L (8.77 mg/L mean measured) adult mortality occurred between day 7 and 14 (100%) and precluded any further analysis on reproduction (EC5021 d, adult mortality: 6.04 mg/L time weighted mean measured concentration). At nominal 22 mg/L (20.1 mg/L mean measured) survival was 100% till day 2 but between day 2 and day 4 100% adult mortality occurred.
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