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Diss Factsheets
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EC number: 265-049-4 | CAS number: 64741-49-7 A complex combination of hydrocarbons produced as the lowest boiling stream in the vacuum distillation of the residuum from atmospheric distillation of crude oil. It consists of hydrocarbons having carbon numbers predominantly in the range of C11 through C25 and boiling in the range of approximately 205°C to 400°C (401°F to 752°F).
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
No experimental data were located on the toxicokinetics of gas oils in vivo, hence other information sources must be used to assess the toxicokinetics of these substances in vivo.
Results of experimental studies in animals provide qualitative evidence of absorption by the lung, as indicated by a modest increase in startle reflex in rats inhaling respirable aerosols of diesel fuel. Physico-chemical considerations also suggest that highly respirable aerosols of poorly water soluble substances with a log Pow greater than zero will be absorbed to some extent from the respiratory tract. In the absence of further guidance, it will be assumed that 50% of an inhaled dose of aerosolised gas oil will be absorbed by animals and humans.
No measured data are available on the dermal absorption of gas oils, however the occurrence of systemic tissue changes in repeated dose toxicity studies (in the absence of dermal irritation, and after controlling for incidental ingestion during grooming) indicates that some absorption across the skin is possible. Results from the SKINPERM model indicate that uptake of gas oil across the skin is likely to be low, with an estimated dermal flux of 0.0001058 mg cm-2.hour for human skin. However the reliability of this value is not known, and therefore complete absorption of gas oil by human skin has been assumed (conservative default) as recommended by the TGD (ECB, 2003). This is probably highly conservative given that the log Pow of the majority (>98.5%) of gas oil components falls outside the 1-4 range that favours dermal uptake (ECB, 2003). Since experimental studies demonstrate greater absorption of lipophilic substances by animal skin compared to human skin, it will be therefore be assumed during risk characterisation that animal skin is 2-fold more permeable to topically applied gas oils than is human skin.
Substances in Vacuum Gas Oils/Hydrocracked Gas Oils/ Distillate Fuels are UVCBs; hence it is not possible to apply standard methodology for assessing absorption, distribution, and metabolism. Relevant data for use in risk assessment are available for key constituents.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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