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Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1964
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1964
Report date:
1964

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion)
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Paraffin waxes and Hydrocarbon waxes, chloro
EC Number:
264-150-0
EC Name:
Paraffin waxes and Hydrocarbon waxes, chloro
Cas Number:
63449-39-8
Molecular formula:
C18H33Cl5 C18H30Cl8 C20H36Cl6 C20H33Cl9 C25H45Cl7 C25H42Cl10 C25H29C23 C30H53Cl9 C30H49Cl13 C30H35Cl27
IUPAC Name:
Paraffin waxes and Hydrocarbon waxes, chloro
Details on test material:
C22-30; 70% Cl (solid) (stabilised). Cereclor 70. Stabilized with 1.0% epoxidised vegetable oil, 0.05% hydrated oxalic acid and 0.05% ethylene glycol.

Test animals / tissue source

Species:
rabbit
Strain:
not specified

Test system

Vehicle:
other: dispersing agent
Controls:
other: one eye in each animal used as control
Amount / concentration applied:
50% suspension
Duration of treatment / exposure:
single dose
Observation period (in vivo):
2 days
Number of animals or in vitro replicates:
3
Details on study design:
A drop of the suspension was placed in one conjunctival sac of three male rabbits.

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
conjunctivae score
Basis:
mean
Time point:
other: 1 hour
Score:
1
Max. score:
1
Reversibility:
fully reversible
Irritation parameter:
conjunctivae score
Basis:
mean
Time point:
other: 1 day
Score:
0
Max. score:
0
Reversibility:
fully reversible
Irritant / corrosive response data:
There was slight congestion of the conjunctiva within one hour but the eyes were completely normal on the following day. Slightly irritating.

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
Not classified as an eye irritant.
Executive summary:

Not classified as an eye irritant.