Registration Dossier
Registration Dossier
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EC number: 200-272-2 | CAS number: 56-40-6
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Test methods and performance uncertain, limited documentation available.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 977
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- Glycine
- EC Number:
- 200-272-2
- EC Name:
- Glycine
- Cas Number:
- 56-40-6
- Molecular formula:
- C2H5NO2
- IUPAC Name:
- glycine
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Age at study initiation: at 7 weeks of age
Weight at study initiation: No data
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 23±2°C
- Humidity (%): 55±5 °C
- Air changes (per hr): No data
- Photoperiod (hrs dark / hrs light): No data
Administration / exposure
- Route of administration:
- intravenous
- Vehicle:
- physiological saline
- Details on exposure:
- Manufacture, supplier, source of supply: Iwai Chemicals Co.
Lot/batch No.: no data - Doses:
- more than 4 doses (unspecified)
- No. of animals per sex per dose:
- 5 - 10 animals/dose
- Control animals:
- not specified
- Details on study design:
- Duration of observation period following administration: 7 days
Frequency of observations and weighing: No data
Necropsy of survivors performed: yes
Other examinations performed: clinical signs - Statistics:
- Litchfield-Wilcoxon method
Results and discussion
Effect levelsopen allclose all
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 2 600 mg/kg bw
- 95% CL:
- > 2 396 - < 2 821
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 2 600 mg/kg bw
- 95% CL:
- > 2 396 - < 2 821
- Mortality:
- no data
- Clinical signs:
- Immediately after dosing, female and male rats showed clonic convulsion, exophthalmos, cyanosis and dyspnea and then, the breath stopped during convulsion.
- Body weight:
- no data
- Gross pathology:
- Congestion in lungs and dot hemorrhage in glandular stomach were observed in some animals. No abnormal gross findings in the other organs were observed.
- Other findings:
- Organ weights: No data
Histopathology: No data
Potential target organs: No data
Other observations: No data
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
