Registration Dossier
Registration Dossier
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EC number: 200-272-2 | CAS number: 56-40-6
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Test methods and performance uncertain, limited documentation available.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 977
Materials and methods
- Principles of method if other than guideline:
- The acute oral toxicity of glycine in mice was investigated.
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Glycine
- EC Number:
- 200-272-2
- EC Name:
- Glycine
- Cas Number:
- 56-40-6
- Molecular formula:
- C2H5NO2
- IUPAC Name:
- glycine
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- other: dd
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Age at study initiation: at 5 weeks of age
Weight at study initiation: No data
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 23±2 °C
- Humidity (%): 55±5°C
- Air changes (per hr): No data
- Photoperiod (hrs dark / hrs light): No data
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- physiological saline
- Details on oral exposure:
- Manufacture, supplier, source of supply: Iwai Chemicals Co.
Lot/batch No.: no data - Doses:
- more than 4 doses (unspecified)
- No. of animals per sex per dose:
- 5 - 10 animals/dose
- Control animals:
- not specified
- Details on study design:
- Duration of observation period following administration: 7 days
Frequency of observations and weighing: no data
Necropsy of survivors performed: yes
Other examinations performed: clinical signs - Statistics:
- Litchfield-Wilcoxon method
Results and discussion
- Preliminary study:
- no data
Effect levelsopen allclose all
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 4 920 mg/kg bw
- 95% CL:
- > 4 413 - < 5 486
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 5 640 mg/kg bw
- 95% CL:
- > 5 036 - < 6 317
- Mortality:
- no data
- Clinical signs:
- other: Decrease in in locomotor activity, slightly respiratory depression, piloerection and ptosis were observed in female and male mice at 15 to 35 min after dosing. Most of the animals stopped breathing after muscle weakness, cyanosis, circular movement, toni
- Gross pathology:
- Congestion in lungs and dot hemorrhage in glandular stomach were observed in some animals. No abnormal gross findings in the other organs were observed.
- Other findings:
- Organ weights: No data
Histopathology: No data
Potential target organs: No data
Other observations: No data
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- CLP: not classified
DSD: not classified
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