Registration Dossier
Registration Dossier
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EC number: 200-272-2 | CAS number: 56-40-6
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
NOEC ≥ 100 mg/L (ready biodegradability test, OECD 301C)
Key value for chemical safety assessment
- EC10 or NOEC for microorganisms:
- 100 mg/L
Additional information
Since no studies on the toxicity of glycine to aquatic microorganisms are available, a ready biodegradability study is used to derive a NOEC for the toxicity to aquatic microorganisms. If a compound degrades well in a ready biodegradability test or does not inhibit the degradation of a positive control at a certain concentration, this concentration can be used as a NOEC value. This approach is in accordance with the Guidance on information requirements and chemical safety assessment (Chapter R.7b: Endpoint specific guidance, ECHA 2008).
The toxicity of glycine to aquatic microorganisms was assessed based on the maximum test concentration (100 mg/L) of the ready biodegradability test (Noguchi, 1993). When present at a concentration of 100 mg/L, glycine attained full degradation and no inhibitory effect of glycine on the microbial activity could be observed. Hence, the NOEC for the toxicity to microorganisms is stated as ≥ 100 mg/L.
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