Registration Dossier

Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Original study not available. Based on IUCLID data summary.

Data source

Reference
Reference Type:
publication
Title:
Acute inhalation toxicity of volatile hydrocarbons
Author:
Swann, H.E., Kwon, B.K., Hogan, G.K., Snellings, W.M.
Year:
1974
Bibliographic source:
Am. Ind. Hyg. Assoc. J., 1974, 35, 511-518

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: no information available
Principles of method if other than guideline:
No information on the method or guideline used was available.
GLP compliance:
no
Test type:
other: no available information
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
No information on the test material used is available.

Test animals

Species:
mouse
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
not specified
Vehicle:
other: no data
Analytical verification of test atmosphere concentrations:
not specified
Remarks on duration:
no information
Concentrations:
No information available.
No. of animals per sex per dose:
No information available. Total of four animals reported.
Control animals:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LCLo
Effect level:
397 mg/L air (nominal)
Clinical signs:
99.2mg/L displayed slight excitation
198mg/L displayed deep anesthesia
397mg/L irregular respiration and respiratory arrest

Applicant's summary and conclusion