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Toxicological information

Basic toxicokinetics

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Administrative data

Endpoint:
basic toxicokinetics in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Original publication not available. Data based on IUCLID data summary sheet.

Data source

Reference
Reference Type:
publication
Title:
Autooxidative injury with loss of cytochrome P-450 following acute exposure of rats of fasting and ether anesthesia.
Author:
Liu, P.T., Symons, A.M., Parke, D.V.
Year:
1991
Bibliographic source:
Xenobiotica, 1991, 21, 205-215

Materials and methods

Objective of study:
metabolism
Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Male rats were fasted for 20 hours and exposed to diethyl ether. Cytochrome P450 levels were monitored.
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
No details on test material available.
Radiolabelling:
no

Test animals

Species:
rat
Strain:
Wistar
Sex:
male

Administration / exposure

Route of administration:
inhalation: vapour
Vehicle:
unchanged (no vehicle)
Duration and frequency of treatment / exposure:
6 min
Doses / concentrations
Remarks:
Doses / Concentrations:
ca. 5000 mg/kg bw
No. of animals per sex per dose:
No data
Control animals:
yes

Results and discussion

Metabolite characterisation studies

Metabolites identified:
not measured
Details on metabolites:
Post exposure there was an increase in exhaled alkanes and indication of lipid peroxidation.

Any other information on results incl. tables

Total cytochrome P-450 levels in the liver and kidney were decreased to 25 -30% of the control animals. Levels were normal 2 hours later.

Cytochrome P-450 I levels were decreased to 35 -44% of the control animals. Levels were 80% 2 hours later.

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): bioaccumulation potential cannot be judged based on study results