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Toxicological information

Additional toxicological data

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Administrative data

Endpoint:
additional toxicological information
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Original publication not available. Data based on IUCLID data summary sheet.

Data source

Reference
Reference Type:
publication
Title:
Reduced synthesis of hepatic and plasma proteins in rats during diethyl ether anesthesia
Author:
Bessesen, A., Smith-Kielland, A., Gadeholt, G., Morland, J.
Year:
1983
Bibliographic source:
Acta Pharmacol. Toxicol., 1983, 54, 241-246

Materials and methods

Type of study / information:
Toxicodynamics study
Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Effect of diethyl ether anesthesia on in vivo hepatic protein synthesis.
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Any other information on results incl. tables

At anesthetic concentrations, the rate of liver protein synthesis was reduced by 20% compared to controls. The secretion of plasma proteins was reduced by 70 -80% compared to controls, or animals receiving pentobarbital.

Applicant's summary and conclusion